Total synthesis of greensporone C |
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Authors: | Kwanruthai Tadpetch Laksamee Jeanmard Vatcharin Rukachaisirikul |
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Affiliation: | Department of Chemistry and Center of Excellence for Innnovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand |
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Abstract: | The first total synthesis of greensporone C, a cytotoxic 14-membered resorcylic acid lactone, has been accomplished via a longest linear sequence of 16 steps in 3.3% overall yield. The key features of the synthesis include Mitsunobu esterification and ring-closing metathesis to construct the macrocycle and establish the (E)-olefin geometry, respectively. Our synthesis also confirmed the absolute stereochemistry of the natural product. |
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Keywords: | Greensporone C Resorcylic acid lactone Total synthesis Ring-closing metathesis |
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