| Oxidative Splitting of a Pyrimidine Cyclobutane Dimer:A Pulse Radiolysis Study |
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| 作者姓名： | 晏利琴 林维真 |
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| 作者单位： | [1]DepartmentofChemistry,UniversityofScienceandTechnologyofChina,Hefei,Anhui230026,China [2]ShanghaiInstituteofnuclearResearch,ChineseAcademyofSciences,Shanghai201800.China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .30 0 0 0 0 36)andDoctoralProgrammefromtheStateEducationCom missionofChina . |
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| 摘 要： | The oxidative splitting process of cis-syn 1,3-dimethyluracil cyclobutane dimer(DMUD) in aqueous solution was investigated using pulse radiolysis technique.The results indicated that DMUD can be splitted into 1,3-dimethyluracil(DMU) by OH radicals(OH) and Br2 radical anions(Br2^-),but not by azide radicals(N3^).The oxidative mechanisms that an H-abstracted from DMUD for OH oxidative splitting and an electron transfer from DMUD to Br2-,were suggested.Related kinetic parameters were determined.
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| 关 键 词： | 嘧啶环丁烷二聚物 氧化裂解 电子转移 脉冲辐解作用 实验研究 紫外光 DNA 辐射损伤 |
Oxidative Splitting of a Pyrimidine Cyclobutane Dimer: A Pulse Radiolysis Study |
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| YAN,Li-Qin a SONG,Qin-Hua,a HEI,Xiao-Ming aGUO,Qing-Xiang a LIN,Wei-Zhen b a.Oxidative Splitting of a Pyrimidine Cyclobutane Dimer:A Pulse Radiolysis Study[J].Chinese Journal of Chemistry,2003,21(1):16-19. |
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| Authors: | YAN Li-Qin a SONG Qin-Hua a HEI Xiao-Ming aGUO Qing-Xiang a LIN Wei-Zhen b a |
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| Institution: | YAN,Li-Qin a SONG,Qin-Hua,a HEI,Xiao-Ming aGUO,Qing-Xiang a LIN,Wei-Zhen b a Department of Chemistry,University of Science and Technology of China,Hefei,Anhui 230026,China b Shanghai Institute of Nuclear Research,Chinese Academy of Sciences,Shanghai 201800,China |
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| Abstract: | The oxidative splitting process of cis‐syn 1,3‐dimethyluracil cyclobutane dimer (DMUD) in aqueous solution was investigated using pulse radiolysis technique. The results indicated that DMUD can be splitted into 1,3‐dimethyluracil (DMU) by OH radicals (OH·) and Br2 radical anions (Br·2?), but not by azide radicals (N·3). The oxidative mechanisms that an H‐abstracted from DMUD for OH· oxidative splitting and an electron transfer from DMUD to Br·2?, were suggested. Related kinetic parameters were determined. |
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| Keywords: | pyrimidine cyclobutane dimer oxidative splitting pulse radiolysis |
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