Highly selective hydroformylation of the cinchona alkaloids |
| |
| Authors: | Lambers Marielle Beijer Felix H Padron José M Toth Imre de Vries Johannes G |
| |
| Affiliation: | DSM Fine Chemicals-Advanced Synthesis & Catalysis, P.O. box 18, 6160 MD Geleen, The Netherlands. |
| |
| Abstract: | The four naturally occurring cinchona alkaloids were subjected to hydroformylation to create an extra functional group that allows immobilization. Cinchonidine, quinine, and quinidine, could be hydroformylated with virtually complete terminal selectivity, using a rhodium/tetraphosphite catalyst. The cinchonidine aldehyde was reduced to the alcohol and subjected to reductive amination with benzylamine. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
