Preparation of 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-one |
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| Authors: | Jian Liu Tianying Jian Liangqin Guo Tzvetomira Atanasova Ravi P. Nargund |
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| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA |
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| Abstract: | A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-one with high yield is reported. The formation of spiro[furanone-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction. |
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| Keywords: | Spiro piperidine Suzuki coupling Iodolactonization |
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