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A new, enantioselective synthesis of (+)-isolaurepan |
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| Authors: | Gonzalo Pazos Yagamare Fall |
| Affiliation: | Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, 36200 Vigo, Spain |
| Abstract: | A highly enantioselective synthesis of 2,6-syn-disubstituted tetrahydropyrans from commercially available tri-O-acetyl-d-glucal, based on a thermal Claisen rearrangement, allows enantioselective synthesis of (+)-isolaurepan when combined with a ring expansion reaction using trimethylsilyldiazomethane. |
| Keywords: | Marine toxins Enantioselective synthesis Claisen rearrangement 26-syn-Disubstituted tetrahydropyrans |
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