Intramolecular-Prins-cyclization: a novel synthesis of hexahydro-2H-furo[3,2-c]pyran derivatives |
| |
| Authors: | J.S. Yadav P. Pawan Chakravarthy Prashant Borkar B.V. Subba Reddy A.V.S. Sarma |
| |
| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| |
| Abstract: | p-Toluenesulfonic acid is found to catalyze the coupling of (Z)-hex-3-ene-1,6-diol with a series of aldehydes by means of intramolecular-Prins-cyclization to provide the corresponding hexahydro-2H-furo[3,2-c]pyran derivatives in good yields with complete cis-selectivity, whereas the coupling of (E)-hex-3-ene-1,6-diol with aliphatic aldehydes gave trans-fused bicyclic furopyrans. |
| |
| Keywords: | Brø nsted acids Intramolecular-Prins-cyclization Angularly fused furopyrans |
| 本文献已被 ScienceDirect 等数据库收录！ |
