Asymmetric synthesis of the core of AMPTD, the key amino acid of microsclerodermins F-I |
| |
| Authors: | Cameron M Burnett |
| |
| Institution: | Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA University of Colorado Cancer Center, Aurora, CO 80045, USA |
| |
| Abstract: | We report a stereoselective synthesis of the five consecutive stereocenters of AMPTD in seven steps. Highlights include an Evans glycolate aldol reaction, the use of a Weinreb amide as an aldehyde masking group, and a Mannich reaction with an Ellman-type chiral sulfimine. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
