Chemo-enzymatic asymmetric total synthesis of penienone |
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| Authors: | Tridib Mahapatra |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India |
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| Abstract: | An asymmetric synthesis of penienone has been accomplished from (R)-5-hydroxymethyl-2-cyclohexenone by adopting a linear strategy. Lipase-PS-catalyzed enzymatic kinetic resolution (EKR) and Julia-Kocienski olefination followed by substrate-directed anionic hydroxymethylation have been successfully employed to achieve the target molecule. |
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