A practical strategy for the synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines |
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Authors: | Chaomin Li Andrew Rosenau |
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Institution: | Merck Research Laboratories-Boston, 33 Avenue Louis Pasteur, Boston, MA 02115, USA |
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Abstract: | Starting from commercially available 4-amino-2,6-dichloropyrimidine, a practical four steps synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines was developed. This strategy could introduce a diverse set of secondary amines and arylamines to displace the 2- and 4-chloro groups. The products of this route are otherwise difficult to access. In addition, 6-amino arylation was carried out to demonstrate the reactivity and utility of 2-dialkylamino-4-arylamino-6-aminopyrimidines as building blocks for assembling interesting aminopyrimidine molecules. |
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