Microwave-assisted synthesis of substituted 2-amino-1H-imidazoles from imidazo[1,2-a]pyrimidines |
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| Authors: | DS Ermolat’ev EV Babaev |
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| Institution: | a Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium
b Chemistry Department, Moscow State University, Moscow 119992, Russia |
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| Abstract: | An efficient method for the synthesis of mono- and disubstituted 2-amino-1H-imidazoles via microwave-assisted hydrazinolysis of substituted imidazo1,2-a]pyrimidines is reported. This protocol avoids strong acidic conditions and is superior to the classical cyclocondensation of α-haloketones with N-acetylguanidine. |
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| Keywords: | Imidazo[1 2-a]pyrimidines Substituted 2-amino-1H-imidazoles Microwave-assisted reaction Hydrazinolysis Ring cleavage |
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