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Determination of absolute configuration of C14−C23 fragment in symbiodinolide |
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| Authors: | Chunguang Han Masaki Kita Daisuke Uemura |
| Affiliation: | a Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan b Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571, Japan c Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan |
| Abstract: | The degradation product C14−C23 2 was obtained using ethenolysis with the 2nd-generation Hoveyda-Grubbs catalyst from 62-membered lactone in symbiodinolide (1). The absolute configurations of three chiral centers in fragment 2 were assigned as 17R, 18R, and 21R by a combination of J-based configuration analysis and the Mosher-Riguera method. |
| Keywords: | Ethenolysis 2nd-generation Hoveyda-Grubbs catalyst Absolute configuration J-based configuration analysis |
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