| Microwave-assisted Polymerization of ε-Caprolactone with Maleic Acid as Initiator and Drug Release Behavior of Ibuprofen-Poly(ε-caprolactone) System |
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| 引用本文： | Ying SONG Li Jian LIU 等.Microwave-assisted Polymerization of ε-Caprolactone with Maleic Acid as Initiator and Drug Release Behavior of Ibuprofen-Poly(ε-caprolactone) System[J].中国化学快报,2003,14(1):32-34. |
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| 作者姓名： | Ying SONG Li Jian LIU |
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| 作者单位： | [1]DepartmentofPolymerScience,CollegeofChemistryandMolecularScience,WuhanUniversityWuhan430072 [2]DepartmentofPolymerScience,CollegeofChemistryandMolecularScience,WuhanUniversityWuhan |
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| 基金项目： | This work was financially supported by the Research Foundation of MOE and National 973 Project of China (G1999064703). |
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| 摘 要： | Poly( ε-caprolactone)(PCL) with weight-average molar mass over 10000g/mol was synthesized by microwave-assisted ring -opening polymerization of ε-caprolactone(ε-CL) with maleic acid(MA) as initiator (2.45GHz,360W,85min),Ibuprofen-PCL controlled release system was prepared directly by the ROP of ε-CL in its mixture with ibuprofen.The release of ibuprofen from the system was sustained and steady.
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| 关 键 词： | 微波化学 聚合反应PLL ε-己内酯 聚(ε-己内酯) 马来酸 开环聚合 药物缓蚀剂 |
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