Optimizing inputs for diagnosis of diabetes. I. Fitting a minimal model to data |
| |
Authors: | R. N. Bergman R. E. Kalaba K. Spingarn |
| |
Affiliation: | (1) University of Southern California, Los Angeles, California;(2) Space and Communications Group, Hughes Aircraft Company, Los Angeles, California |
| |
Abstract: | A glucose tolerance test was performed on dogs by injecting glucose intravenously and measuring the plasma glucose and insulin concentrations versus time. Various analytical and computational techniques were utilized to fit the data to a minimal model and to estimate the parameters of the blood glucose regulation process. A relatively good fit was obtained in spite of the rather simple model.Animal experiments were funded by the National Institute of Health Grant No. AM-17236 awarded to Dr. R. N. Bergman at U.S.C. |
| |
Keywords: | Parameter estimation least-square estimation glucose tolerance test blood glucose regulation empirical data |
本文献已被 SpringerLink 等数据库收录! |