| 几种血卟啉3,8-烷氧(硫)基衍生物产生单重态氧能力的研究 |
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| 引用本文： | 陈暨耀,陆亚蒙,陈士明,蔡怀新,许德余,张浩. 几种血卟啉3,8-烷氧(硫)基衍生物产生单重态氧能力的研究[J]. 影像科学与光化学, 1991, 9(2): 156-159. DOI: 10.7517/j.issn.1674-0475.1991.02.156 |
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| 作者姓名： | 陈暨耀 陆亚蒙 陈士明 蔡怀新 许德余 张浩 |
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| 作者单位： | 1. 复旦大学物理系、分析测试中心 上海 200433;2. 第二军医大学抗疟药研究室 上海 200433 |
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| 摘 要： | 在“血卟啉衍生物”(HPD)[1]肿瘤光动力疗法取得令人瞩目成就的同时,化学家们证明了临床使用的HPD制剂并非原意义上的血卟啉衍生物,而是一种复杂的卟啉混合物[2],其中血卟啉(HP),羟乙基-乙烯基-次卟啉(HVD),原卟啉(PP)约占总量的80%,Dougherty等分离得到其余20%未知结构羧基卟啉,认为此为HPD的有效成分,经进一步分析测定其主要成分是二血卟啉醚(DHE)[3]。
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| 关 键 词： | 血卟啉衍生物 电子顺磁共振 单重态氧 |
| 收稿时间： | 1990-03-26 |
THE ABILITY OF SOME HEMATOPORPHYRIN 3,8-ALKYLOXY (THIO) DERIVATIVE FOR PHOTO-GENERATING SINGLET OXYGEN |
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| CHEN JI-YAO,Lu YA-MENG,CHEN SHI-MING,CAI HUAI-XIN,Xu DE-YU,ZHANG HAO. THE ABILITY OF SOME HEMATOPORPHYRIN 3,8-ALKYLOXY (THIO) DERIVATIVE FOR PHOTO-GENERATING SINGLET OXYGEN[J]. Imaging Science and Photochemistry, 1991, 9(2): 156-159. DOI: 10.7517/j.issn.1674-0475.1991.02.156 |
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| Authors: | CHEN JI-YAO Lu YA-MENG CHEN SHI-MING CAI HUAI-XIN Xu DE-YU ZHANG HAO |
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| Affiliation: | 1. Physics department. Analysis and measurement centre, Fudan University, Shanghai, 200433, P. R. China;2. Second Military Medical College, Shanghai, 200453, P. R. China |
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| Abstract: | Photosensitization of some individual hematoporphyrin 3,8-alkyloxy (thio) derivatives was studied by ESR method. According to the increasing intensities of ESR signal of nitroxyl free radical products, the ability of these compounds, for photo-generting singlet oxygen was evaluated. The results shown that different hematoporphyrin derivative has considerable infuence on the sensitization abilities, which reveals a way to explore new porphyrin photosensitizer by changing its derivatives. |
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| Keywords: | Hematoporphyrin derivative electron spin resonance singlet oxygen |
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