Urea co-inclusion compounds of glipizide for the improvement of dissolution profile |
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Authors: | Seema Thakral A. K. Madan |
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Affiliation: | (1) GVM College of Pharmacy, Sonipat, 131 001, India;(2) Faculty of Pharmaceutical Sciences, M.D. University, Rohtak, 124 001, India |
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Abstract: | In the present study, urea, a well-known adductor for linear compounds was successfully utilized for inclusion of glipizide—a highly substituted cyclic organic compound through a modified technique. Formation of glipizide co-inclusion compounds in urea was confirmed by FTIR, DSC and XRD. The minimum proportion of rapidly adductible endocyte (RAE) required for adduction of glipizide in urea was estimated by a modified Zimmerschied calorimetric method. Urea–GLP–RAE inclusion compounds containing varying proportions of guests were prepared and their thermal behaviour studied by DSC. The co-inclusion compounds were found to exhibit good content uniformity. Through the formation of co-inclusion compounds of urea, it was possible to achieve steep improvement in the dissolution efficiency of glipizide, which is a BCS class II drug. |
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Keywords: | Adduction Complexation Content uniformity Dissolution rate Glipizide Urea inclusion compounds |
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