Design and synthesis of pyrankacin: a pyranmycin class of broad-spectrum aminoglycoside antibiotic |
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| Authors: | Rai Ravi Chen Hsiao-Nung Czyryca Przemyslaw G Li Jie Chang Cheng-Wei Tom |
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| Affiliation: | Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, USA. |
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| Abstract: | [STRUCTURE: SEE TEXT] A novel broad-spectrum aminoglycoside antibiotic, pyrankacin, has been prepared. In addition to the synthetic innovation in dideoxygenation and regioselective Staudinger reduction, we have obtained prominent antibacterial activity against several clinically important pathogens in the course of this work. |
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