Local Photodynamic Therapy Reduces Tissue Hyperplasia in an Experimental Restenosis Model |
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| Authors: | Peter Gonschior Florian Gerheuser Michael Fleuchaus Tanya Y Huehns Alwin E Goetz Ulrich Welsch Ronald Sroka Marc Dellian Hans A Lehr Berthold Höfling |
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| Institution: | Medical Department I, Klinikum GroBhadem, Ludwig-Maximilians University, Munich, Germany;Institute of Anesthesia, Klinikum GroBhadem, Ludwig-Maximilians University, Munich, Germany;Institute of Anatomy, Ludwig-Maximilians University, Munich, Germany;GSF Laser Research Department, Munich, Germany;Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA and Department of Pathology, University of Washington, Seattle, WA, USA |
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| Abstract: | Abstract— Local photodynamic therapy may have potential in preventing myointimal hyperplasia after angioplasty. In this study, the effect of photodynamic therapy was evaluated in an experimental model of restenosis. Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries. Animals were randomly allocated to four groups: group 1, unidirectional injury only; group 2, injury followed by local delivery of photosensitizer; group 3, injury followed by local exposure to monochromatic light; and group 4, where injury was followed by local drug delivery of photosensitizer and subsequent exposure to light (photodynamic therapy). Seven, 14 or 21 days after treatment, all experimental vessels were excised, fixed and processed for histology. An inflammatory and myoproliferative response was observed after injury in vessels from groups 1, 2 and 3. In group 4, after injury followed by photodynamic therapy, the myoproliferative response was significantly reduced. Thus, in this study, tissue hyperplasia after unidirectional injury was effectively suppressed by photodynamic therapy. |
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