Vilsmeier-type reaction of dimethylaminoalkenoyl cyclopropanes: one-pot access to 2,3-dihydrofuro [3,2-c]pyridin-4(5H)-ones |
| |
Authors: | Huang Peng Zhang Ning Zhang Rui Dong Dewen |
| |
Affiliation: | Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. |
| |
Abstract: | A domino reaction of readily available 1-carbamoyl-1-dimethylaminoalkenoylcyclopropanes in the presence of triflic anhydride (Tf(2)O) in N,N-dimethylformamide (DMF) is described, which provides a facile one-pot access to 2,3-dihydrofuro[3,2-c]pyridin-4(5H)-ones via tandem formylation (Vilsmeier-type reaction), intramolecular cyclization, and ring-enlargement sequences. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|