A biomimetic approach to lanthionines |
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Authors: | Aydillo Carlos Avenoza Alberto Busto Jesús H Jiménez-Osés Gonzalo Peregrina Jesús M Zurbano María M |
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Institution: | Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, U.A.-C.S.I.C., E-26006 Logro?o, Spain. |
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Abstract: | The asymmetric sulfa-Michael additions of appropriately protected L- and D-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin. |
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