Synthesis of tricyclic nitrogen heterocycles by a sequence of palladium-catalyzed N-H and C(sp3)-H arylations |
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Authors: | Guyonnet Mathieu Baudoin Olivier |
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Affiliation: | CNRS UMR 5246 - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université Claude Bernard Lyon 1 , CPE Lyon, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France. |
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Abstract: | A range of tricyclic nitrogen heterocycles were synthesized in a straightforward and efficient manner via a sequence involving palladium-catalyzed N-arylation and C(sp(3))-H arylation as the key steps. Whereas the C(sp(3))-H arylation furnished fused 6,5,6-membered ring systems efficiently, the formation of the more strained 6,5,5-membered systems proved to be more challenging and required a subtle adjustment of the reaction conditions. |
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