Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties |
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Authors: | Vergara Elena Cerrada Elena Clavel Catherine Casini Angela Laguna Mariano |
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Affiliation: | Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH)-C.S.I.C, Universidad de Zaragoza, 50009, Zaragoza, Spain. |
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Abstract: | A series of thiolate gold(I) derivatives bearing water soluble phosphanes--namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA)--is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe(2)pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds. |
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