Ring-expansion of tertiary cyclic alpha-vinylamines by tandem conjugate addition to (p-toluenesulfonyl)ethyne and formal 3-aza-Cope rearrangement |
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Authors: | Weston Mitchell H Nakajima Katsumasa Parvez Masood Back Thomas G |
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Institution: | Department of Chemistry, University of Calgary, Calgary, AB, CanadaT2N 1N4. |
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Abstract: | A novel ring-expansion protocol is based on the conjugate additions of cyclic alpha-vinylamines to (p-toluenesulfonyl)ethyne, followed by aza-Cope rearrangements of the resulting zwitterions, to afford medium and large-ring cyclic amines under remarkably mild conditions. |
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