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Synthesis of novel uracil based 2,5-diaminofurans using multi-component reactions |
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| Authors: | Robabeh Baharfar Seyed Meysam Baghbanian |
| Institution: | Department of Chemistry, University of Mazandaran, P. O. Box 47415, Babolsar, Iran |
| Abstract: | A simple synthesis of highly functionalized 2,5-diaminofurans based pyrimidine derivatives from l-(carboxymefhyl)uracil via a multi-component reaction is described.The reactive 1:1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by l-(carboxymethyl)uracil derivatives to yield polyfunctionalized furan rings in fairly good yields. |
| Keywords: | Multi-component reactions 2 5-Diaminofurans l-(Carboxymethyl)uraciI /erf-Butyl isocyanidc Dialkyl acctylene-dicarboxylate |
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