Facile synthesis of novel fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazole |
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Authors: | Xin Jian Songa Zheng Chao Duana Yu Shaoa Xing Gao Dongb a |
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Affiliation: | Key Laboratory of Biological Resources Protection and Utilization of Hubei Province, Hubei University for Nationalities, Enshi 445000, China ; Medical School, Hubei University for Nationalities, Enshi 445000, China |
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Abstract: | A series of novel fluorinated thieno[2,3-d]pyrimidine derivatives incorporating 1,3,4-thiadiazole were synthesized by a facile microwave-assisted procedure,including the cyclization of 2-aminothiophene-3-carbonitrile with trifluoroacetic acid,chlorination and nucleophilic substitution reaction.This protocol offered such advantages as mild reaction conditions,short reaction time, simple puritication and good yields.The structures of the products were characterized by ~1H NMR,MS,elemental analysis and Xray diffraction. |
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Keywords: | Thieno[2.3-d]pyrimidine 1,3,4-Thiadiazole Trifluoromethyl Microwave-assisted synthesis |
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