| Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting |
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| 引用本文： | Lei Tang Yong Wu Jiao Lu Zhi Rong Zhang Jin Cheng Yang Li Hai. Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting[J]. 中国化学快报, 2007, 18(5): 513-515. DOI: 10.1016/j.cclet.2007.03.018 |
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| 作者姓名： | Lei Tang Yong Wu Jiao Lu Zhi Rong Zhang Jin Cheng Yang Li Hai |
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| 作者单位： | Lei Tang，Yong Wu，Jiao Lu，Zhi Rong Zhang，Jin Cheng Yang，Li Hai Key Laboratory of Drug Targeting Education Ministry，West China School of Pharmacy，Sichuan University，Chengdu 610041，PR China |
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| 摘 要： | A novel bifunctional compound carrying cluster thiogalactoside as the cell targeting ligands was synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly(ethylene glycol) chain. This design provided an effective entry for the synthesis of the bifunctional compound.
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| 关 键 词： | 肝细胞特异性递送 三触角型半乳糖苷 合成 靶向配基 受体介导药物传输 |
| 收稿时间： | 2006-12-04 |
Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting |
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| Lei Tang,Yong Wu,Jiao Lu,Zhi Rong Zhang,Jin Cheng Yang,Li Hai. Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting[J]. Chinese Chemical Letters, 2007, 18(5): 513-515. DOI: 10.1016/j.cclet.2007.03.018 |
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| Authors: | Lei Tang Yong Wu Jiao Lu Zhi Rong Zhang Jin Cheng Yang Li Hai |
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| Affiliation: | Key Laboratory of Drug Targeting Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China |
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| Abstract: | A novel bifunctional compound carrying cluster thiogalactoside as the cell targeting ligands was synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly(ethylene glycol) chain. This design provided an effective entry for the synthesis of the bifunctional compound. |
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| Keywords: | Cluster Cholesterylated galactoside Targeting ligand Hepatocyte-specific delivery Gene delivery |
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