Research on imidazo[1,2-a] benzimidazole derivatives |
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Authors: | V. A. Anisimova N. I. Avdyunina A. M. Simonov G. V. Kovalev S. M. Gofman |
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Affiliation: | (1) Scientific-Research Institute of Physical and Organic Chemistry, Rostov State University, Rostov-on-Don;(2) Volgograd Medical Institute, USSR |
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Abstract: | ,-Unsaturated ketones of the imidazo[1,2-a]benztmidazole series were synthesized from 3-formyl- and 3-acetyl-substituted imidazo[1,2-a]benzimidazoles by crotonic condensation in the presence of alkaline catalysts. The ,-unsaturated ketones can also be obtained by direct acylation of 3-unsubstituted imidazo[1,2-a]benzimidazoles with the chlorides of unsaturated acids. The properties and pharmacological activity of the ketones obtained were studied.See [1] for communication XIII.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1660–1665, December, 1976. |
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