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Measurement of pH values in human tissues by two-photon microscopy |
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| Authors: | Park Hee Jung Lim Chang Su Kim Eun Sun Han Ji Hee Lee Tae Hee Chun Hoon Jai Cho Bong Rae |
| Institution: | Department of Chemistry, Korea University, Anam-ro, Sungbuk-gu, Seoul, Korea. |
| Abstract: | pH values go live! A ratiometric two-photon (TP) probe (NP1, see scheme) that has a significant TP action cross-section, high photostability, negligible toxicity, and can estimate pH values in live cells and human tissues by two-photon microscopy is described. NP1 can detect the difference in pH between live cells from the gastroesophageal junction (GEJ) and the lower esophageal sphincter of patients with and without esophagitis. |
| Keywords: | fluorescent probes imaging agents live‐cell imaging naphthalenes two‐photon microscopy |
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