Ceramicines E-I, new limonoids from Chisocheton ceramicus |
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| Authors: | Wong Chin Piow Shimada Misae Nagakura Yuta Nugroho Alfarius Eko Hirasawa Yusuke Kaneda Toshio Awang Khalijah Hadi A Hamid A Mohamad Khalit Shiro Motoo Morita Hiroshi |
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| Institution: | Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. |
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| Abstract: | Five new limonoids, ceramicines E-I (1-5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E-I (1-5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis. |
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