Coordination properties of cefadroxil antibiotic: synthesis and equilibrium studies of the binary and ternary complexes involving amino acids and DNA units

The formation equilibria for the binary complexes of Cu(II), Ni(II), Co(II), Zn(II), Mn(II), Hg(II), Cd(II), Ca(II), and Mg(II) with cefadroxil (Cef) and for the ternary complexes Cu(Cef)(L), where L refers to amino acid or DNA, were investigated. The protonation constants of cefadroxil and formation constants of the formed complexes were determined at 25 degrees C and mu = 0.1 M NaNo(3). Cooper(II) and cobalt(II) complexes of cefadroxil were isolated in solid state and characterized by elemental analysis, infrared and electronic spectral, conductivity and magnetic measurement.