Elaboration of fluorescent and highly magnetic submicronic polymer particles via a stepwise heterocoagulation process |
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Authors: | M. Lansalot M. Sabor A. Elaissari C. Pichot |
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Affiliation: | (1) Systémes Macromoléculaires et Physiopathologie Humaine, UMR 2714 - 46, allée d’Italie, 69364 Lyon Cedex 07, France |
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Abstract: | Using the stepwise heterocoagulation concept, fluorescent and highly magnetic submicronic core-shell polymer particles were prepared. For this purpose a negatively charged oil-in-water magnetic emulsion was first modified by adsorbing the poly(ethyleneimine) (PEI). Secondly, low glass transition temperature (T g=10°C) anionic film-forming nanoparticles were adsorbed onto the cationic magnetic droplets. Finally the encapsulation was induced by heating the heterocoagulates above the T g of the film-forming nanoparticles. To produce labeled magnetic particles, fluorescent nanoparticles and film-forming nanoparticles were simultaneously adsorbed. PEI adsorption was investigated. Also investigated was the influence of the amount of film-forming nanoparticles and fluorescent nanoparticles on the encapsulation efficiency. |
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Keywords: | Heterocoagulation Submicronic particles Magnetic emulsion Fluorescent |
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