Acide 2-fluoro-2-phényl propanoïque: préparation et utilisation comme agent chiral de dérivation

The enantiomers of 2-fluoro-2-phenyl propanoic acid have been separated and theirabsolute configurations determined: the specific rotation of the acid with an R configurationis ]²⁰_D= −28.5° (c = 1.5, ethanol). This acid has been used as a chiral derivatizingagent. Esters and amides prepared from this acid and chiral alcohols or amines presentimportant fluorine chemical shift differences between the diastereoisomers