Catalyst-free and solvent-free synthesis of novel symmetrical bisthioglycolic acid derivatives |
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| Authors: | Baharak Pooladian Ehsan Ghasemi |
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| Affiliation: | Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran |
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| Abstract: | A simple, efficient, eco-friendly, and cost-effective method has been developed for the synthesis of symmetrical bisthioglycolic acid derivatives by a one-pot reaction of aldehydes or ketones with thioglycolic acid under solvent- and catalyst-free conditions in excellent yields (87–97%). The advantages of this novel protocol include the excellent yields, operational simplicity, short reaction times, and the avoidance of the use of organic solvents and catalysts. |
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| Keywords: | thioglycolic acid catalyst-free solvent-free thioethers aldehydes |
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