Efficient one-pot synthesis of ethyl 2-substitued-4-methylthiazole-5-carboxylates |
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Authors: | Ge Meng Mei Wang Aqun Zheng Jianwei Dou |
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Affiliation: | 1. School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, P. R. China;2. School of Science, Xi'an Jiaotong University, Xi'an, P. R. China |
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Abstract: | A new and practical one-pot procedure for the synthesis of several 2-sustituted-4-methylthiazole-5-carboxylates from commercially available starting materials is described. Under mild reaction conditions, some of the products with alkyl group on the 2-amino group or with various groups on 2-substituted phenyl ring were obtained in good yields from ethyl acetoacetate, N-bromosuccinimide, thiourea, or its N-substituted derivatives in an efficient way instead of the traditional two-step reaction. |
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Keywords: | N, S-heterocyle thiourea ethyl 2-substituted-4-methylthiazole-5-carboxylates cyclization |
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