| ε-己内酯与D,L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价 |
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| 引用本文： | 宋存先,冯新德. ε-己内酯与D,L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价[J]. 高分子学报, 1986, 0(2): 108-114 |
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| 作者姓名： | 宋存先 冯新德 |
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| 作者单位： | 中国医学科学院生物医学工程研究所 天津(宋存先)，北京大学化学系 北京(冯新德) |
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| 摘 要： | “活性”中间体PCL-PLA-OAl<用环氧乙烷扩链生成含聚醚羟端基的预聚物,它与Teyssie催化剂反应后取代其中的异丙氧基生成“活性”的预聚物催化体系,进而引发CL 聚合生成PCL-PLA-PCL ABA型嵌段共聚物,它的机械性能优于AB型共聚物,断裂伸长增大约一倍,具有微观相分离结构和可控制的生物降解性能及药物释放性能。本文亦提供了内酯与交酯嵌段共聚的新途径。
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| 收稿时间： | 1983-11-22 |
SYNTHESIS AND EVALUATION OF BIODEGRADABLE ABA TRIBLOCK COPOLYMER OF δ-CAPROLACTONE AND DL-LACTIDE AS DRUG RELEASE DELIVERY |
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| SONG Cun-xian,FENG Xin-de. SYNTHESIS AND EVALUATION OF BIODEGRADABLE ABA TRIBLOCK COPOLYMER OF δ-CAPROLACTONE AND DL-LACTIDE AS DRUG RELEASE DELIVERY[J]. Acta Polymerica Sinica, 1986, 0(2): 108-114 |
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| Authors: | SONG Cun-xian FENG Xin-de |
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| Affiliation: | The Institute of Biomedical Engineering; Chinese Academy of Medical Sciences; Tianjing; Department of Chemistry; Peking University; Beijing |
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| Abstract: | The growing AB block copolymer intermediate (PCL-PLA-OAi ) was extendedwith ethylene oxide at room temperature to form a HO-terminated PEO end-capped prepolymer which reacted with Teyssie catalyst, and replaced its isopropoxy groups toform an active prepolymeraupported catalyst, PCL-PLA-OCH2CH2-OAl . Ithas been proved that this prepolymer-supported catalyst was able to initiate CL polymerization in toluene at 90℃. The ABA triblocg copolymens with different length of segments with biodegradable as well as tough menbrane-forming properties have been synthesized successfully. This new synthetic method would provide a potential pothway from polylaetide to form block copolymers with lactones. |
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