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| Synthesis and Immunosuppressive Activity of New Amino Alcohol Derivatives(Ⅰ) | |
| 基金项目： | Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co.Ltd |
| 摘 要： | |
Synthesis and Immunosuppressive Activity of New Amino Alcohol Derivatives(Ⅰ) |
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| Authors: | MI Hao-yu CUI Lin-lin ZHANG Qun-li LI Fang JIANG Tao LIANG Yong-tao WANG En-si College of Life Science Jilin University Changchun PRChina School of Pharmacy Changchun |
| Institution: | MI Hao-yu1,CUI Lin-lin1,ZHANG Qun-li1,LI Fang2,JIANG Tao2,LIANG Yong-tao1 and WANG En-si1,2 1.College of Life Science,Jilin University,Changchun 130012,P.R.China,2.School of Pharmacy,Changchun 130021 |
| Abstract: | A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases. |
| Keywords: | Immunosuppressant Amino alcohol derivative Bucherer-Bergs reaction |
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