Synthesis of New Flavanone Derivatives of Farrerol and Preliminary SAR Studies on Anti-VSMCs Vegetation Activity |
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| Authors: | SHI Lei FENG Xiu-e LIN Wen-han FANG Lian-hua DU Guan-hua LI Qing-shan . School of Pharmaceutical Science Shanxi Medical University Taiyuan P. R. China . State Key Laboratory of Natural Biomimetic Drugs Peking University Beijing |
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| Affiliation: | SHI Lei1,FENG Xiu-e1,LIN Wen-han2,FANG Lian-hua3,DU Guan-hua3 and LI Qing-shan1,2* 1. School of Pharmaceutical Science,Shanxi Medical University,Taiyuan 030001,P. R. China,2. State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100083,3. Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050 |
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| Abstract: | A series of new flavanone derivatives of farrerol was designed and synthesized as a potent inhibitor of vascular smooth muscle cells(VSMCs) vegetation according to a convenient method. The structures of all the synthesized compounds were confirmed by 1H NMR, 13C NMR and EIHR-MS. The biological activities of these compounds against VSMCs in vitro were evaluated. The assay results indicate that two compounds, 5,7-dihydroxy-6,8-dimethyl- 2-(2-nitrophenyl)chroman-4-one(7f) and 2,3-dibromo-4,5-dihydroxydiphenylm... |
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| Keywords: | Synthesis Flavanone derivative Anti-VSMCs vegetation |
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