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Anti-tumor Immune Response Mediated by Newcastle Disease Virus HN Gene
Authors:PENG Li-ping  LI Xiao  SUN Li-li  WEN Zhong-mei  LIU Yan  GAO Peng  HUANG Hai-yan  PIAO Bing-guo  JIN Jing   JIN Ning-yi
Affiliation:PENG Li-ping1,2,LI Xiao2,SUN Li-li2,3,WEN Zhong-mei1,LIU Yan2,4,GAO Peng2,5,HUANG Hai-yan2,PIAO Bing-guo2,JIN Jing2,6 and JIN Ning-yi2* 1. Department of Respiratory Medicine,the First Hospital of Jilin University,Changchun 130021,P. R. China,2. Genetic Engineering Laboratory of PLA,the Eleventh Institute of Academy of Military Medical Sciences of PLA,Changchun 130062,3. Head and Neck Surgery,the Tumor Hospital of Jilin Province,Changchun 130012,4. Department...
Abstract:Hemagglutinin-neuramidinase(HN) is one of the most important surface structure proteins of the Newcastle disease virus(NDV). HN not only mediates receptor recognition but also possesses neuraminidase(NA) activity, which gives it the ability to cleave a component of those receptors, NAcneu. Previous studies have demonstrated that HN has interesting anti-neoplastic and immune-stimulating properties in mammalian species, including humans. To explore the application of the HN gene in cancer gene therapy, we con...
Keywords:HN gene  Recombined adenovirus  Cytokine  Cell immunity  Anti-tumor activity  
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