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Anti-tumor Immune Response Mediated by Newcastle Disease Virus HN Gene |
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| Authors: | PENG Li-ping LI Xiao SUN Li-li WEN Zhong-mei LIU Yan GAO Peng HUANG Hai-yan PIAO Bing-guo JIN Jing JIN Ning-yi |
| Affiliation: | PENG Li-ping1,2,LI Xiao2,SUN Li-li2,3,WEN Zhong-mei1,LIU Yan2,4,GAO Peng2,5,HUANG Hai-yan2,PIAO Bing-guo2,JIN Jing2,6 and JIN Ning-yi2* 1. Department of Respiratory Medicine,the First Hospital of Jilin University,Changchun 130021,P. R. China,2. Genetic Engineering Laboratory of PLA,the Eleventh Institute of Academy of Military Medical Sciences of PLA,Changchun 130062,3. Head and Neck Surgery,the Tumor Hospital of Jilin Province,Changchun 130012,4. Department... |
| Abstract: | Hemagglutinin-neuramidinase(HN) is one of the most important surface structure proteins of the Newcastle disease virus(NDV). HN not only mediates receptor recognition but also possesses neuraminidase(NA) activity, which gives it the ability to cleave a component of those receptors, NAcneu. Previous studies have demonstrated that HN has interesting anti-neoplastic and immune-stimulating properties in mammalian species, including humans. To explore the application of the HN gene in cancer gene therapy, we con... |
| Keywords: | HN gene Recombined adenovirus Cytokine Cell immunity Anti-tumor activity |
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