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EPR Effect of Amphiphilic Copolymer Micelles Observed by Fluorescent Imaging |
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| Authors: | LIU Tong-jun LIU Shi HU Xiu-li SHENG Shi-hou HUANG Yu-bin JING Xia-bin |
| Affiliation: | LIU Tong-jun1,LIU Shi2,HU Xiu-li2,SHENG Shi-hou1,HUANG Yu-bin2 and JING Xia-bin2 1.Department of Colorectal and Anal Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,P.R.China,2.State Key Laboratory of Polymer Physics and Chemistry,Changchun Institue of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022 |
| Abstract: | Enhanced permeation and retention(EPR) targeting effect of rhodamine B labeled PEG-b-P(LA-co-DHP) [PEG:poly(ethylene glycol);LA:L-lactide;DHP:2,2-dihydroxylmethyl-propylene carbonate] micelles(RhB-micelles) was observed in H22 liver cancer bearing mice.The RhB-micelles were prepared by conjugating rhodamine B with the DHP units of amphiphilic block copolymer PEG-b-P(LA-co-DHP) followed by subsequent self-assembling of the conjugate.The parent copolymer PEG-b-P(LA-co-DHP) was synthesized by ring-opening copo... |
| Keywords: | Enhanced permeability and retention(EPR) effect Fluorescent imaging Micelle Passive targeting |
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