Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes |
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| Authors: | WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan Tianjin Key Laboratory of Composite Functional Materials School of Materials Science Engineering Tianjin University Tianjin P.R.China |
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| Affiliation: | WU Li-li,LI Xiao-ran,LI Hua and YUAN Xiao-yan Tianjin Key Laboratory of Composite and Functional Materials,School of Materials Science and Engineering,Tianjin University,Tianjin 300072,P.R.China |
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| Abstract: | In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly(L-lactide-co-glycolide)(PLGA),hybrid PLGA and chitosan(H-PLGA/CS),and core/shell PLGA/CS (C-PLGA/CS),were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,respectively.Bovine serum albumin(BSA) was selected as a model protein.The loading efficiency of BSA in the PLGA membrane was 1.56%,lower than those of H-PLGA/CS(5.98%) and C-PLGA/CS(4.80%).BSA release profiles from the th... |
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| Keywords: | Controlled release Bovine serum albumin Electrospun membrane Poly(L-lactide-co-glycolide) Chitosan |
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