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Construction, Expression and Characterization of a Chimeric Protein Targeting Carcinoembryonic Antigen in Lung Cancer |
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| Authors: | LI Yang HUA Shu-cheng MA Cheng-yuan YU Zhen-xiang XU Li-jun LI Dan SUN Li-li LI Xiao PENG Li-ping |
| Affiliation: | LI Yang1,HUA Shu-cheng1,MA Cheng-yuan2,YU Zhen-xiang1,XU Li-jun1,LI Dan1,SUN Li-li3,LI Xiao4 and PENG Li-ping1* 1. Department of Respiration,2. Department of Neurosurgery,the First Hospital of Jilin University,Changchun 130021,P. R. China,3. Department of Head and Neck Surgery,Tumor Hospital of Jilin Province,Changchun 130012,4. Laboratory of Genetic Engineering of PLA,Academy of Military Medical Sciences,Changchun 130062 |
| Abstract: | The carcinoembryonic antigen(CEA) is an oncofetal glycoprotein known as an important clinical tumor marker and is overexpressed in several types of tumors, including colorectal and lung carcinomas. We constructed a chimeric protein that exhibits both specific binding and immune stimulating activities, by fusing staphylococcal enterotoxin A(SEA) to the C-terminus of an anti-CEA single-chain disulfide-stabilized Fv(scdsFv) antibody (single-chain-C-terminus/SEA, SC-C/SEA). The SC-C/SEA protein was expressed in... |
| Keywords: | Carcinoembryonic antigen Staphylococcal enterotoxin A Single-chain disulfide-stabilized Fv(scdsFv) Escherichia coli Anti-tumor immunity |
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