Coumarin derivatives as promising antibacterial agent(s) |
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| Authors: | Chita Ranjan Sahoo Jyotirmaya Sahoo Monalisa Mahapatra Debananda Lenka Pratap Kumar Sahu Budheswar Dehury Rabindra Nath Padhy Sudhir Kumar Paidesetty |
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| Institution: | 1. Central Research Laboratory, IMS & SUM Hospital, Siksha O Anusandhan Deemed to be University, Bhubaneswar, India;2. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, India;3. School of Pharmacy, ARKA JAIN University, Gamharia, Seraikela Kharsawan, Jameshedpur, Jharkand, India;4. Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, India;5. Biomedical Informatics Centre, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India |
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| Abstract: | Nowadays, bacterial infections epitomize significant health threats globally with an increased morbidity and mortality. Most contemporary antibacterial agents are resisted by pathogenic bacteria - the multidrug resistant (MDR) bacterial strains arising from cross resistances operative in natural bacterial consortia inside human body and in environments. Consequently, the development of newer potential drug candidate(s) is required against the broad spectrum of MDR bacteria. Indeed, the phytochemical coumarin and its derivatives had been reported with broad biological inhibitory properties, including antibacterial activities. In this review, several methods of synthetic strategies of coumarin derivatives as antibacterials were considered with individual schematic compounds by structure-activity relationship (SAR) studies as essential corollaries. Overall, substituents at positions C-3 and C-4 of coumarin are coveted for the development of newer antibacterial agents. |
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| Keywords: | Coumarin Semi-synthesis Antibacterial Structural-activity-relationship |
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