Copper oxide nanopowder modified carbon paste electrode for the voltammetric assay of vonoprazan |
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Authors: | Salhah D Al-Qahtani Samar Y Al-nami |
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Institution: | 1. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia;2. Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia |
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Abstract: | Vonoprazan (VPZ) is a novel promising member of gastric acid-suppressive medicinal administrated in Japan in 2015. Only a few HPLC analysis protocols were reported for VPZ assaying, therefore, the present work describes for the first time a novel copper oxide nanoparticles-based sensor as a promising analytical tool for differential pulse voltammetric determination of vonoprazan with enhanced sensitivity compared with the bare electrode. An irreversible oxidation process with the two-electron transfer was elucidated with scan rate measurements. At the optimized conditions, peak heights showed against VPZ in the concentration range from 0.99 to 20.00 µg mL?1, and detection limit of 0.24 µg mL?1. The proposed sensor showed prolonged stability with a 95% recovery of the original peak height within the first 30 days. Good reproducibility and repeatability of the fabrication protocol was reported with RSD 1.3%. Noticeable resolution between the VPZ, ascorbic acid, and uric voltammetric peaks allows accurate assaying of VPZ in biological fluids with average recoveries agreeable with the conventional HPLC techniques. |
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Keywords: | Vonoprazan Differential pulse voltammetry Carbon paste electrode Copper oxide nanoparticles |
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