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Design,synthesis, in silico and in vitro evaluation of novel diphenyl ether derivatives as potential antitubercular agents |
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| Authors: | Tiwari Ashutosh Prasad Sridhar B Boshoff Helena I Arora Kriti Gautham Shenoy G Vandana K E Varadaraj Bhat G |
| Institution: | 1.Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India ;2.X-ray Crystallography Division, CSIR – Indian Institute of Chemical Technology, Hyderabad, 500607, India ;3.Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA ;4.Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, India ; |
| Abstract: | Molecular Diversity - Diphenyl ether derivatives inhibit mycobacterial cell wall synthesis by inhibiting an enzyme, enoyl-acyl carrier protein reductase (InhA), which catalyses the last step in the... |
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