Decorated CuO nanoparticles over chitosan-functionalized magnetic nanoparticles: Investigation of its anti-colon carcinoma and anti-gastric cancer effects |
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| Authors: | Yuping Wang Attalla F El-Kott Ayman E El-Kenawy Liangjun Xue |
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| Institution: | 1. Department of Oncology Wards 1, Henan Province Hospital of TCM (The Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou City, Henan Province 450000, China;2. Biology Department, College of Science, King Khalid University, Abha 61413, Saudi Arabia;3. Zoology Department, College of Science, Damanhour University, Damanhour 22511, Egypt;4. Pathology Department, College of Medicine, Taif University, Taif 11099, Saudi Arabia;5. Department of Radiotherapy, Yijishan Hospital of Wannan Medical College, Wuhu 241001, China |
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| Abstract: | In this study, a green protocol for supporting CuO nanoparticles over chitosan-modified amino-magnetic nanoparticles is described. The physicochemical and morphological properties of the desired nanocomposite assessed by various techniques like ICP, FT-IR, FE-SEM, EDX, TEM, XRD and VSM. In the oncological part of the recent study, the Cu(NO3)2, Fe3O4, and Fe3O4-NH2@CS/CuO nanocomposite cell viability was very low against human gastric cancer cell lines i.e. MKN45, AGS, and KATO III and human colorectal carcinoma cell lines i.e. HT-29, HCT 116, HCT-8 HRT-18], and Ramos.2G6.4C10. The IC50 of Fe3O4-NH2@CS/CuO nanocomposite against MKN45, AGS, KATO III, HT-29, HCT 116, HCT-8 HRT-18], and Ramos.2G6.4C10 cell lines were 517, 525, 544, 282, 214, 420, and 477 µg/mL, respectively. Thereby, the best anti-gastro-duodenal cancers findings of our Fe3O4-NH2@CS/CuO nanocomposite was seen in the HCT 116 cell line case. |
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| Keywords: | Copper oxide Chitosan Magnetic nanocomposite Gastric cancer Colorectal carcinoma |
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