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Indium-111 labeled bleomycin for targeting diagnosis and therapy of liver tumor: optimized preparation,biodistribution and SPECT imaging with xenograft models |
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| Authors: | Tang Yu Liu Weihao Li Feize Chen Lin Wang Mingshuang Hu Yingjiang Liao Zhonghui Chen Yue Li Shufen Liao Jiali Yang Jijun Yang Yuanyou Liu Ning |
| Institution: | 1.Key Laboratory of Radiation Physics and Technology (Sichuan University), Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, People’s Republic of China ;2.Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University & Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, 646000, People’s Republic of China ;3.Guo Ke Rong’ an Biological Technology (Beijing) Co. Ltd., Beijing, 100097, People’s Republic of China ; |
| Abstract: | In this work, the preparation of 111In radiolabeled bleomycin (111In-BLM) was optimized systematically and used for SPECT imaging of liver cancer xenograft models. 111In-BLM with a high radiochemical yield (>?99%) could be obtained at pH 0.5–1 at a mixture ratio of 9:1 (111In/BLM, mCi/mg). The radiochemical purity of 111In-BLM retained?>?99% in either buffers or serum for 3 days. Biodistribution of 111In-BLM revealed its excellent stability in vivo. The SPECT imaging studies showed 111In-BLM has great specificity to liver tumor xenograft. All the results implied 111In-BLM is a potential radiopharmaceutical for targeting diagnosis and therapy of liver tumor. |
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