| Co(phen)33+与6-巯基嘌呤及DNA间相互作用的研究 |
| |
| 引用本文： | 周翠凤,李 红,乐学义.Co(phen)33+与6-巯基嘌呤及DNA间相互作用的研究[J].无机化学学报,2004,20(1):115-118. |
| |
| 作者姓名： | 周翠凤 李 红 乐学义 |
| |
| 作者单位： | 1. 华南师范大学化学系,广州,510631
2. 华南农业大学理学院,广州,510642 |
| |
| 基金项目： | 广东省自然科学基金资助项目(No.990452) |
| |
| 摘 要： | 自1969年首次报道顺铂(cis-Pt(NH 3 ) 2 Cl 2 ])对肿瘤有强烈抑制作用以来,金属配合物抗肿瘤药物的研究倍受重视 1,2] ?很多抗肿瘤药物治疗恶性肿瘤疾病都是通过切割人体肿瘤细胞的DNA来实现的?DNA与外源性分子相互作用的研究构成肿瘤形成的机理和一些抗肿瘤药物作用机理的基
|
| 关 键 词： | 6-巯基嘌呤 Co(phen)33+ DNA 相互作用 |
| 修稿时间： | 2003年7月10日 |
Studies on the Interaction among Co(phen)33+, 6-Mercaptopurine and DNA |
| |
| ZHOU Cui-Feng,LI Hong and LE Xue-Yi.Studies on the Interaction among Co(phen)33+, 6-Mercaptopurine and DNA[J].Chinese Journal of Inorganic Chemistry,2004,20(1):115-118. |
| |
| Authors: | ZHOU Cui-Feng LI Hong and LE Xue-Yi |
| |
| Institution: | Department of Chemistry, South China Normal University, Guangzhou 510631,Department of Chemistry, South China Normal University, Guangzhou 510631 and College of Science, South China Agricultural University, Guangzhou 510642 |
| |
| Abstract: | The interaction among Co(phen)33+, 6-Mercaptopurine(6-MP) and calf thymus DNA has been investigated using cyclic voltammetry, differential pulse voltammetry and UV-spectra in Tris buffer solutions(pH=7.2). In the presence of 6-MP, the redox peak current at 0.15 V for the central cobalt ion from voltammograms is significantly reduced compared with that in the absence of 6-MP and the current of a new quasi-reversible redox wave shown at -0.06 V gradually increases with 6-MP addition. However, when DNA is further added, the peak current at 0.15 V is renewedly enlarged and the redox at -0.06 V gradually disappears with DNA addition. At the same time, UV-spectra of Co(phen)33+ are regularly changed in the presence of 6-MP and DNA. All results indicate that the obvious interaction equilibrium is proved to exist among Co(phen)33+, 6-MP and calf thymus DNA. |
| |
| Keywords: | 6-Mercaptopurine Co(phen)33+ DNA interaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《无机化学学报》浏览原始摘要信息 |
| 点击此处可从《无机化学学报》下载免费的PDF全文 |
|
