Polymer-supported bisBINOL ligands for the immobilization of multicomponent asymmetric catalysts |
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Authors: | Sekiguti Tetuya Iizuka Yoshimasa Takizawa Shinobu Jayaprakash Doss Arai Takayoshi Sasai Hiroaki |
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Affiliation: | The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan. |
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Abstract: | [reaction: see text] Polymer-supported bisBINOL ligands were successfully utilized for the immobilization of multicomponent asymmetric catalysts. The polymer-supported Al-Li-bis(binaphthoxide) (ALB) catalyst was more effective than the dendrimer-supported ALB in the Michael reaction of 2-cyclohexen-1-one with dibenzyl malonate affording the adduct in 91% yield with 96% ee. The polymer was also effective for the immobilization of a mu-oxodititanium complex that promoted carbonyl-ene reaction of ethyl glyoxalate with alpha-methyl styrene to provide the adduct with up to 98% ee. |
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