U-pin polyamide motif for recognition of the DNA minor groove |
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Authors: | Heckel Alexander Dervan Peter B |
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Institution: | California Institute of Technology, Division of Chemistry and Chemical Engineering, The Beckman Institute, Pasadena, CA 91125, USA. |
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Abstract: | DNA-binding hairpin pyrrole-imidazole polyamides with gamma-aminobutyric acid as a turn-forming residue tolerate A.T or T.A base pairs under the turn. U-pins-polyamides with a different turn-have been synthesized and their DNA binding properties were studied. The two turn-forming residues are connected via the ring nitrogens using variable length aliphatic linkers ((CH(2))(n), n=3-6). Through optimization of the linker length and the substituents at the 2-position of the pyrrole residue on the U-turn, polyamides with G.C/C.G tolerant turns could be found, which bind to DNA in a predictable manner. |
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Keywords: | amino acids DNA recognition pyrrole–imidazole polyamides U‐pins |
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