Substrate-controlled highly diastereoselective synthesis of primary and secondary diorganozinc reagents by hydroboration/boron-zinc exchange sequence |
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| Authors: | Hupe Eike Calaza M Isabel Knochel Paul |
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| Institution: | Department Chemie, Ludwig-Maximilians-Universit?t, Munich, Germany. |
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| Abstract: | The scope of substrate-controlled diastereoselective hydroborations can be considerably enhanced by a boron-zinc exchange reaction, providing organozinc derivatives that react with a broad range of electrophiles. Even normally unreactive boronic esters, obtained by Rh-catalyzed hydroboration with catecholborane, react readily with iPr2Zn providing the corresponding zinc reagents in high diastereoselectivity. |
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| Keywords: | C?C coupling diastereoselective synthesis hydroboration transmetallation zinc organometallics |
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