Recent advances of injectable hydrogels for drug delivery and tissue engineering applications |
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| Affiliation: | 1. Theranostic Macromolecules Research Center and School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic of Korea;2. National Key Lab for Polymer & Composite and Faculty of Materials Technology, Ho Chi Minh City University of Technology, Vietnam National University – Ho Chi Minh City, Ho Chi Minh City, Viet Nam;1. Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31 Hyoja-dong, Nam-gu, Pohang, Kyungbuk 790-784, Republic of Korea;2. Department of Bioengineering, University of Washington, Box 355061, Seattle, WA 98195, USA;3. Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 65 Landsdowne St. UP-5, Cambridge, MA 02139, USA;1. Department of Agricultural & Biological Engineering, University of Florida, PO Box 110570, Gainesville, FL 32611-0570, United States;2. Ministry of Forestry Bioethanol Research Center, Central South University of Forestry and Technology, Changsha, Hunan, 410004, China;3. Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, PO Box 100215, Gainesville, FL, 32610, United States;4. Department of Microbiology and Cell Science & UF Genetics Institute, PO Box 103610, Gainesville, FL 32611, United States;5. Department of Biomedical Engineering, Widener University, Chester, PA 19013, United States;1. Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela 769008, India;2. Department of Chemistry, SRM Institute of Science and Technology, Kanchipuram, Tamil Nadu, 603203, India;3. SABIC Polymer Reserch Center, Department of Chemical Engineering, King Saud University, Riyadh, Saudi Arabia;4. Department of International Agricultural Technology & Institute of Green BioScience and Technology, Seoul National University, Gwangwon-do 25354, Republic of Korea |
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| Abstract: | Injectable hydrogel is a kind of in situ gelling system but has its specificity on the process procedure, which requires a better control of gelation kinetics. Hydrogels with injectability under mild condition are preferred in the field of biomedicine, especially for drug delivery and tissue engineering, because of the favorable carrier property in three-dimension, biocompatibility, low invasive and adaptable shape for administration. Despite the advantages, the development of injectable hydrogels may also face some challenges to meet the various clinical requirements. In this review, we provide a brief summary on the recent progresses on the design, synthesis and evaluation of injectable hydrogels towards biomedical applications. |
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| Keywords: | Injectable hydrogel Crosslinking mechanisms Drug delivery Tissue engineering |
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